Obesity trials and translational science at Vanderbilt.
A clinical trials portfolio and a translational laboratory arm, with investigators in surgery, endocrinology, infectious diseases, epidemiology, biostatistics, and biomedical informatics.
Four registered studies, including a phase 3 industry trial.
Candidates for our investigator-initiated trials are identified by automated screening in the electronic health record.
Feasibility inquiries: feasibility@vcott.org
Choose your path
- I am evaluating this site for a study Population, catchment, screening method, startup interval, and a named contact. Also available as a printable capability profile.
- I am looking for an open study One study is enrolling now. Each links to its ClinicalTrials.gov record.
- I am a researcher at VUMC or elsewhere Member investigators, the translational science arm, specimen collection, and how to work with the group.
About VCOTT
VCOTT, the Vanderbilt Collaborative for Obesity Trials and Translational science, is a clinical and translational research group at Vanderbilt University Medical Center in Nashville, Tennessee. It conducts interventional, observational, and mechanistic studies in which obesity is the condition under study, with a single point of contact for sponsors.
- Studies
- Four registered on ClinicalTrials.gov: three interventional, one observational; one enrolling now
- Industry trials
- One industry-sponsored trial (phase 3, enrollment complete). The current site principal investigator is a VCOTT co-director.
- Identification
- Automated screening in the electronic health record for investigator-initiated trials
- Co-directors
- Jason M. Samuels, MD, FACS, clinical trials; Charles Robert Flynn, PhD, translational science
- Members
- Investigators in surgery, endocrinology, infectious diseases, epidemiology, biostatistics, and biomedical informatics
- Feasibility
- feasibility@vcott.org
The Obesity Research Working Group meets monthly and currently convenes by invitation. Research with VCOTT
Studies
| Study | Design | Status | Registry |
|---|---|---|---|
| TABS |
Interventional, investigator-initiated | Enrolling | NCT07011628 |
| GRABS Design and baseline paper, Diabetes Obes Metab, 2026 |
Interventional, investigator-initiated, phase 2/3 | Enrollment complete | NCT06162715 |
| REFORM |
Observational | Enrollment complete | NCT07115069 |
| LUCIDITY |
Interventional, industry-sponsored, phase 3 | Enrollment complete | NCT06747468 |
Identification and screening
VCOTT's investigator-initiated trials identify candidates through automated screening in the electronic health record, applied to the active patient population rather than to the clinic schedule. Screening yield before and after implementation is being measured and will be reported here when available.